Potomac Affinity Proteins, LLC is currently developing proteases for use in life science research, in medical diagnostics, in biodefense, and in therapeutics.

Our approach to protease engineering is to create simple components that can be assembled into more complex, multi-component enzymatic machines.  Simple components, once fully characterized, can be combined to form switches, signal amplifiers, and transducers.  

Proteases are particularly useful to incorporate into enzymatic machines because, in addition to generating optical signals, they can also modify other proteins in reaction cascades. Analogous to sophisticated electronic devices built from standard components, an enormous potential exists for creating enzymatic machines that link diverse enzymatic function.


 

Potomac Affinity Proteins, LLC is currently developing proteases for use in life science research, in medical diagnostics, in biodefense, and in therapeutics.

Our approach to protease engineering is to create simple components that can be assembled into more complex, multi-component enzymatic machines.  Simple components, once fully characterized, can be combined to form switches, signal amplifiers, and transducers.  

Proteases are particularly useful to incorporate into enzymatic machines because, in addition to generating optical signals, they can also modify other proteins in reaction cascades. Analogous to sophisticated electronic devices built from standard components, an enormous potential exists for creating enzymatic machines that link diverse enzymatic function.


 

Potomac Affinity Proteins, LLC is currently developing proteases for use in life science research, in medical diagnostics, in biodefense, and in therapeutics.

Our approach to protease engineering is to create simple components that can be assembled into more complex, multi-component enzymatic machines.  Simple components, once fully characterized, can be combined to form switches, signal amplifiers, and transducers.  

Proteases are particularly useful to incorporate into enzymatic machines because, in addition to generating optical signals, they can also modify other proteins in reaction cascades. Analogous to sophisticated electronic devices built from standard components, an enormous potential exists for creating enzymatic machines that link diverse enzymatic function.


 

Potomac Affinity Proteins, LLC is currently developing proteases for use in life science research, in medical diagnostics, in biodefense, and in therapeutics.

Our approach to protease engineering is to create simple components that can be assembled into more complex, multi-component enzymatic machines.  Simple components, once fully characterized, can be combined to form switches, signal amplifiers, and transducers.  

Proteases are particularly useful to incorporate into enzymatic machines because, in addition to generating optical signals, they can also modify other proteins in reaction cascades. Analogous to sophisticated electronic devices built from standard components, an enormous potential exists for creating enzymatic machines that link diverse enzymatic function.


 

Potomac Affinity Proteins, LLC is currently developing proteases for use in life science research, in medical diagnostics, in biodefense, and in therapeutics.

Our approach to protease engineering is to create simple components that can be assembled into more complex, multi-component enzymatic machines.  Simple components, once fully characterized, can be combined to form switches, signal amplifiers, and transducers.  

Proteases are particularly useful to incorporate into enzymatic machines because, in addition to generating optical signals, they can also modify other proteins in reaction cascades. Analogous to sophisticated electronic devices built from standard components, an enormous potential exists for creating enzymatic machines that link diverse enzymatic function.


 

Nature Communications Biology

05 March 2021

Engineering subtilisin proteases

that specifically degrade active RAS

RAS.webp
Target sequence (QEEYSAM) in RAS and in the active site of a RAS-specific protease
prodomain subtilisin complex.jpg

Potomac Affinity Proteins, LLC is currently developing proteases for use in life science research, in medical diagnostics, in biodefense, and in therapeutics.

Our approach to protease engineering is to create simple components that can be assembled into more complex, multi-component enzymatic machines.  Simple components, once fully characterized, can be combined to form switches, signal amplifiers, and transducers.  

Proteases are particularly useful to incorporate into enzymatic machines because, in addition to generating optical signals, they can also modify other proteins in reaction cascades. Analogous to sophisticated electronic devices built from standard components, an enormous potential exists for creating enzymatic machines that link diverse enzymatic function.