Protease Chain Reaction (Pro-CR)
Guide to symbols

Initiating Protease

We want to detect and determine the concentration of this initiating protease.

Self Amplifying Complex

This complex is inactive. The C-shaped inhibitor prevents cutting by the protease. 

Self Amplifying Protease

This is the active version of the above complex. When the inhibitor is cut, the protease activates and cuts the inhibitors of other blue complexes.


Signaling Peptide

When cut by the amplifying protease, it becomes fluorescent and detectable.