Potomac Affinity Proteins, LLC is currently developing proteases for use in life science research, in medical diagnostics, in biodefense, and in therapeutics.
Our approach to protease engineering is to
create simple components that can be assembled into more complex,
multi-component enzymatic machines. Simple components, once fully characterized, can be
combined to form switches, signal amplifiers, and transducers.
Proteases are particularly useful to incorporate into enzymatic machines because, in addition to
generating optical signals, they can also modify other proteins in reaction
to sophisticated electronic devices built from standard components, an
enormous potential exists for creating enzymatic machines that link diverse