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Core mission: To engineer proteases with novel properties for use in life science research, in medical diagnostics, in biodefense and in therapeutics.
Technologies 

Protease Chain Reaction
with Bio Rad Labs


Proteases for Proteomics



Overview



Potomac Affinity Proteins, LLC is currently developing proteases for use in life science research, in medical diagnostics, in biodefense, and in therapeutics.

Our approach to protease engineering is to create simple components that can be assembled into more complex, multi-component enzymatic machines.  Simple components, once fully characterized, can be combined to form switches, signal amplifiers, and transducers. 

Proteases are particularly useful to incorporate into enzymatic machines because, in addition to generating optical signals, they can also modify other proteins in reaction cascades.
Analogous to sophisticated electronic devices built from standard components, an enormous potential exists for creating enzymatic machines that link diverse enzymatic function.